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Important context: While worsening heart failure events were meaningfully reduced, cardiovascular deaths were numerically higher in the tirzepatide group at 2.2% versus 1.4% in the placebo group
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The clinical and metabolic benefits were apparent in patients with T2D with or without heart failure at baseline and were considered largely independent of HbA1c reduction
This high overall GI rate (while mostly mild) likely reflects the combined GI effects of activating both GLP-1 and amylin pathways simultaneously
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