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THC, the primary psychoactive compound found in cannabis, influences appetite and metabolism, so it can have an effect on the efficacy of GLP-1 drugs

A separate KFF analysis from March about Medicare Part D spending data from the Centers for Medicare & Medicaid Services found that gross Medicare spending on the three newest versions of GLP-1 diabetes medicines (Ozempic, Rybelsus and Mounjaro) that also have been approved for weight loss skyrocketed from $57 million in 2018 to $5.7 billion in 2022

This makes GLP-1 therapy a more accessible option for individuals who may be sensitive to medication

Most of the essential nutrients, including amino acids, neurotransmitters, hormones, small peptides, etc., as well as small lipophilic molecules or therapeutic agents, enter the brain by facilitated diffusion [63]