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In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached
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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)
Target: 400600 mcg daily by Weeks 58+
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