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It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

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The gap between choosing the right compound and choosing based on marketing claims comes down to understanding what each peptide actually does at the receptor level

These cells, which accumulate with age, no longer divide but resist programmed cell death, contributing to inflammation and tissue dysfunction