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[4] While observational and legacy data from the UKPDS study suggest potential cardiovascular benefits, metformin does not have proven cardiovascular outcome benefits in the same way as newer agents like GLP-1 receptor agonists or SGLT2 inhibitors

Estos efectos se logran si se realiza ejercicio cardiovascular por lo menos 4 veces a la semana y se sigue una dieta baja en carbohidratos y grasas

The random-effects model used in the analysis addresses this variation to some extent, but the underlying causes of the heterogeneity warrant further investigation

This can be done without requiring the user to go on strict diets or obsessively exercise