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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction
Tissue Health During Weight Loss Significant weight loss involves metabolic and structural remodeling throughout the body
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The Cleveland Clinic notes that bariatric surgery patients are at increased risk for vitamin deficiencies and often require ongoing supplementation: Individuals Using GLP-1 Medications GLP-1 receptor agonists (such as semaglutide and tirzepatide) are commonly used for metabolic health and weight management
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