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No, you should not skip a week of Wegovy

Heart Fail Rev 25:2130 Giannitsi S, Bougiakli M, Bechlioulis A, Naka K (2019) Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation

You may lose more weight on Wegovy than on Qsymia So, while it would be ideal to know if either Qsymia is more effective than Wegovy or the other way around, we have no such information because the question has not been tested before