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Zinc promotes proliferation and activation of myogenic cells via the PI3K/Akt and ERK signaling cascade
In addition to supporting the delivery of growth factors and nutrients to RGCs, glial cells also play a primary role in removing excess glutamate from the extracellular space to prevent RGC damage associated with glutamate excitotoxicity [91, 98, 99]
In BCATi-treated Mmut p.L690Ins/p.L690Ins mice, M0 C3 was elevated in liver and plasma compared with Mmut WT/WT controls (Figure 7E), but C3 levels were not different in BCATi-treated compared with untreated Mmut p.L690Ins/p.L690Ins mice
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