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It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols

Almost every property that distinguishes it from an ordinary short peptide, its color, its pH sensitivity, its incompatibility with chelators and reducing agents, its awkward behavior in mass spectrometry and reversed-phase chromatography, is a property of the metal center rather than of the peptide

Injectable GHK-Cu is used off-label by some peptide-oriented clinicians

My blood work at day 30 showed borderline-high sodium levels