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Thus, the patient can eat a low-calorie diet and ultimately experience weight loss
Some return to semaglutide later at a lower maintenance dose rather than fully stopping, creating a cyclical or on-and-off approach
Many patients struggle with constant hunger, portion control, and weight loss plateaus
We propose that chronic exposure to GLP-1 signalling promotes mTOR-dependent metabolic reprograming via activation of the HIF-1 transcriptional program
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