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The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity
Comparatively, Mounjaro (with the active ingredient tirzepatide) differs from semaglutide and is prescribed at different starting doses, which may contribute to more severe side effects for some individuals
If you need to look across related non-insulin diabetes medicines, the GLP-1 agonists category can help separate class options
Adderall and phentermine are both central nervous system stimulants
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