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Food and Drug Administration (FDA) and are not required to undergo large clinical trials to prove safety, effectiveness (including consistent absorption), and manufacturing quality

Participants with type 2 diabetes lost weight somewhat more slowly than those without diabetes (19.7% versus 24.2% at 48 weeks in the Phase 2 trial), though the difference narrowed at higher doses

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Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery , 18 (12), 13451356