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The historical context of this research dates back to the 1970s when the therapeutic potential of lithium was first recognized
Nevertheless, the presence of active comparators such as GLP-1 RAs with cardioprotective effects would underestimate the efficacy of tirzepatide for cardiometabolic abnormalities, suggesting that the effect estimates represent the lower bounds of the expected effects in the absence of such a comparator
Citing recent anecdotal reports purporting an association of delayed gastric emptying with use of GLP-1 receptor agonists and increased risk of regurgitation and pulmonary aspiration during general anesthesia and deep sedation, the ASA task force set forth to provide the community with guidance on scheduled elective procedures for patients who are using GLP-1 receptor agonists
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