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Compared to wild-type BoNT/X protease, both X(PC2)b, an earlier evolutionary intermediate with activity on both VAMP1 and procaspase-1, and X(PC) demonstrated more stringent substrate requirements (Fig
& Luo, J
Its efficacy was further linked to the modulation of key metabolic pathways, including arginine biosynthesis and arachidonic acid metabolism, which are correlated with inflammation (Qu et al., 2025)
The 12-week mark is where clinical trials documented the strongest improvements in laxity, density, and thickness
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