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MALE FERTILITY AND SPERMATOGENESIS Hypogonadotropic Hypogonadism: Steroidogenesis Restoration Serum testosterone: increase from 200 ng/dL above baseline Primary failure: no response (Leydig cell damage) Secondary failure: present response but low baseline Applications: Differentiation between primary and secondary hypogonadism Pre-pubertal Leydig cell reserve evaluation Treatment response prediction 5

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Ketter PM, Yu JJ, Guentzel MN, May HC, Gupta R, Eppinger M et al

Ordinary two-way ANOVA followed by Sidaks multiple comparisons test was performed and P values were plotted: n = 3, DF = 12