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[1] [2] Combination therapy is typically considered when monotherapy or dual therapy with other agents (such as metformin) fails to achieve adequate glycaemic targets, or when patients require additional cardiovascular or renal protection

If you experience any swelling whilst taking a GLP-1 medication, consider these practical steps: Review all your medications with your pharmacist or GP, as some drugs (calcium channel blockers, NSAIDs, corticosteroids) are more likely to cause fluid retention Monitor your salt intake excessive dietary sodium can contribute to water retention Elevate your legs when sitting or lying down if you have ankle swelling Wear compression stockings if recommended by your healthcare provider (after DVT has been excluded and if appropriate for your circulation) Keep a symptom diary , noting when swelling occurs, its severity, and any associated symptoms Regular monitoring is essential for all patients on GLP-1 therapy

For people living with RA, especially those also living with obesity, diabetes, or increased cardiovascular risk, they may offer benefits beyond blood sugar regulation

They can rule out other causes of your symptoms and discuss whether a GLP-1 is clinically appropriate for you based on your BMI, blood sugar levels, and medical history