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Description

NAC also maintains mitochondrial redox homeostasis by activating the SIRT3-SOD2-GPX4 signaling pathway, thus reducing the ferroptosis rate in the context of DN

The k red value of 1.4 10 6 M 1 s 1 for PfGrx C88S (SH) 2 is about two orders of magnitude higher than the highest k ox value for PfGrx C32S/C88S (SSG) in accordance with a physiological relevance of glutaredoxins as deglutathionylating enzymes

Most patients tolerate the treatment well