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Studies in diet-induced obese animal models have demonstrated that chronic MC4R agonist treatment produces substantial weight loss accompanied by improved glucose tolerance and insulin sensitivity

We hypothesize that adding a long-acting GLP-1-RA can increase basal GLP-1 levels and, in combination with native post-prandial GLP-1 bolus restored after MBS, may be considered as a basal-bolus treatment for individuals with MBS failure (Fig

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