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Exploring weight loss solutions: bariatric surgery As weight loss solutions go, bariatric surgery predates the rise of GLP-1 medications by several decades, with history documenting the first procedure in the early 1950s (although some historians argue the idea of using surgery to promote weight loss existed as early as the 10th century)

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For all GH secretagogues, the long-term concern is chronically elevated IGF-1 levels