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Diabetes Res Clin Pract 76:132-138, 2007
The improved insulin sensitivity after GLP-1MK-801 treatment was confirmed in a 2-week study that, in addition to the pharmacological groups, included a calorie-restricted group weight-matched to the GLP-1MK-801 group (Extended Data Fig
Also in that trial, T2D and obesity were not inclusion criteria and the median BMI at baseline was 28 kg/m 2 in the liraglutide group and 29.8 kg/m 2 in the placebo group
What has changed is not the feasibility of developing drugs without complete biological knowledge, but the expectation that developers be transparent about what is and is not known, and that uncertainty be actively managed rather than minimized (ICH E9 guidance
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