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To determine if GSH depletion-induced oxidative stress impairs mitochondrial biogenesis, we used MitoTracker Red to stain live mitochondria

Disruption of this delicate balance due to various factors, such as iron overload, senescence, and hormones (estrogen and glucocorticoid), can lead to osteoporosis ( Figure 5 )

Eventually, GABA is removed from the system by converting it into succinate, which is then used in the Krebs cycle in the mitochondria to make ATP.[ref] The enzyme succinic semialdehyde dehydrogenase ( ALDH5A1 gene) is needed to convert GABA into succinate.[ref] Rare genetic mutations in the ALDH5A1 gene cause succinic semialdehyde dehydrogenase deficiency, which decreases the breakdown of GABA

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