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Age-related changes: Young cartilage has higher cell density, better matrix quality, superior healing responses

For instance, albiglutide (73.0 kDa) is composed of two copies of a modified GLP-1 (residues 736) fused in tandem to the N-terminal end of wild-type (WT) human albumin 10,28

Across these end-points the reported pattern is consistent: aged animals treated with the peptide trend toward biomarker profiles characteristic of younger animals, although effect sizes are typically modest and methods of measurement vary across publications

Acknowledgments The authors thank the co-workers of the Institute of Animal Nutrition and the co-workers of the experimental station of the Friedrich-Loeffler-Institut in Braunschweig for their great support, as well as all other members of the MitoCow team