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Important distinction: chronic insomnia is assessed through sleep onset, awakenings, total sleep time, sleep efficiency, daytime effects and patient experience
14 Two therapeutic strategies currently exist to overcome the short half-life of incretin hormones and pharmacologically augment the incretin effect: 1) inject GLP-1 receptor agonists that are resistant to degradation by the DPP-4 enzyme and 2) orally administer DPP-4 inhibitors that delay the enzymatic degradation of naturally secreted incretin hormones ( Figure 2 )
Staying hydrated is especially important while taking GLP-1s
