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The inositol requiring enzyme 1 alpha (IRE1) induced thioredoxin-interacting protein (TXNIP)/NLRP3 pathway activation and subsequent pyroptosis have been observed in both HG-exposed NRK-52E cells and diabetic rats (45)
[73] and Canadian guidelines for FASD diagnoses, which established criteria for diagnosing FASD in Canada and harmonized most differences between the IOM and the University of Washington's systems
The GPX family contains eight members (GPX1-GPX8), of which GPX1-GPX4 and GPX6 (human) members have an active center of selenocysteine, which is an important selenoprotein in mammals (Table 1)
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