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J Eur Acad Dermatol Venereol 34(Suppl 5):2126
Elevated growth hormone may support tissue repair, metabolic regulation, and potentially ovarian follicle quality via IGF1 signaling
TNF- induces inflammation by preparing leukocytes to synthesize oxidants, triggering prostaglandin and other inflammatory mediators, and causing adhesion molecules to be produced, attracting leukocytes to tissue injury sites [55]
Critically, these decidualization and matrix remodeling defects do not occur in isolation: they frequently co-occur with immune dysregulation, suggesting that RIF may represent a syndrome of coordinated endometrial dysfunction rather than a single-pathway failure [287, 297]
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