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It is generally safe but not recommended for pregnant or breastfeeding women
Indole-3-acetic acid (IAA), produced by gut microbiota, alleviates fibrosis by suppressing PI3K/AKT/mTOR signaling, enhancing autophagy, and reducing fibroblast activation and epithelial senescence [114]
The peptide signals tissue remodeling, collagen and elastin synthesis, and gene expression linked to wound repair
Furthermore, preclinical data help determine optimal dosing and duration of SFN administration, as well as identifying potential biomarkers for response, such as reduced inflammatory markers or improved mitochondrial function
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