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NanoBRET data were further normalized to define the minimum and maximum response to the corresponding endogenous ligand, using the GraphPad Prism software package (version 7.02, GraphPad Software, San Diego, CA)

When functioning properly, this sphincter opens to allow food passage into the stomach, then closes tightly to prevent acidic contents from traveling upward

Reconstitution and administration for both peptides Both cagrilintide and retatrutide are typically supplied as lyophilized (freeze-dried) powders that require reconstitution with bacteriostatic water before use