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Current British Society of Gastroenterology guidance suggests considering a baseline upper GI endoscopy with biopsies in adults aged 50 or over with confirmed pernicious anaemia to document autoimmune gastritis

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10.1007/3-540-37673-9_1 Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases 109 SongG

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk