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For Dr Sinclair, the unknowns of the knock-off retatrutide are the primary concern
Retatrutide is currently in Phase 3 clinical trials as of March 2026
This is remarkable progress given the historical trends with previous anti-obesity medications used (i.e., Phentermine, Low Dose Naltrexone, Orlistat, etc.) were only noted to produce an average of 3-7% total percentage of body weight lost
30 which found that liraglutide, another GLP-1 receptor agonist, decreased heroin, another opioid, self-administration under long-access (in their case 6 hours) conditions
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