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There was also no evidence of heterogeneity observed across the included trials regarding fatal or non-fatal stroke (I 2 = 4%, Cochran Q test P = 0.39) (see Fig
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More studies are revealing that these drugs can also improve brain health
It attaches to the KISS1R (GPR54) receptor in the hypothalamus and directly induces GnRH release
In the subgroup of newer incretin-based therapies (including semaglutide and tirzepatide), the average regain rate was higher (about 1.8 pounds per month), which tracks with the fact that these drugs also produce greater initial weight loss
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