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Levine, A
Senescent macrophages exhibit a significant increase in Pro-inflammatory and immunomodulatory cytokines and chemokines (including TNF-, IL-6, and IL-1), diminished autophagic function, impaired antiviral capabilities, and downregulation of glycolysis and mitochondrial oxidative phosphorylation, ultimately leading to a state of energy depletion 36
Chronic alcohol use can lead to dysregulation of dopaminergic pathways, which is often observed in individuals with depression
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