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Safety and Side Effects Both peptides have favorable safety profiles in animal studies and in the human case-series data clinicians have accumulated

GLP-1 receptor stimulation can increase dopaminergic neuron activity via a presynaptic mechanism of action in the ventral tegmental area (VTA) (21) and increase the expression of dopamine transporter on the neuronal cell surface to reduce free dopamine levels in the synapses in LS and striatal brain (22, 23)