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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
The culprit is a compromised delivery system, one that oral intake alone cannot always overcome
Finerenone Finerenone is a non-steroidal mineralocorticoid receptor antagonist (contrast with spironolactone, a steroidal mineralocorticoid RA) that has been shown to reduce the risk of CKD progression (Bakris et al, 2020) and improve CV outcomes (Pitt et al, 2022) compared to placebo in randomised controlled trials in subjects with type 2 diabetes and albuminuric CKD
injections of 100 nmol kg 1 MK-801 ( n = 8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 (Cys-linked) ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 5 days
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