Berberine, an isoquinoline alkaloid from Berberis spp., has demonstrated promising antioxidant activity via promoting heme oxygenase-1 (HO-1) expression, activating Nrf2/AMPK/SIRT1 signaling, inhibiting the NLRP3 inflammasome, balancing glutathione levels, and regulating mitochondrial redox processes (Sunhe et al., 2024
It wasnt controversial, political or even staged
It activates both GIP and GLP-1 receptors, which decreases appetite, slows gastric emptying, and improves the hormonal environment around glucose metabolism
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