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Transcriptomic analysis further revealed that various cuproptosis-related genes (such as GLS, DLST, LIPT1) are differentially expressed in COPD lung tissues and are associated with lung function indicators and the frequency of acute exacerbations (129)
Selective pretreatment of endothelial cells with methylene blue before co-culture with untreated rabbit pulmonary arterial smooth muscle produced a reduction in rabbit pulmonary arterial smooth muscle cyclic guanosine monophosphate levels of a magnitude comparable with that seen in cocultures of methylene blue pretreated rabbit pulmonary arterial smooth muscle with untreated endothelial cells, and which was partially prevented by superoxide dismutase
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