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In spite of their limitations, these studies are the first to demonstrate a capacity of exogenously administered NAC to reach the CNS
Six trials totaling roughly 900 participants are summarized in Stier et al
However, current research has not shown any significant risk, and duloxetine does not inhibit the MAO enzyme
It is precisely because the effect is short and self-limiting that the pituitarys own feedback machinery remains in charge, and it is that feature, more than any other, that supporters cite when they describe secretagogues as working with rather than over the endocrine axis
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