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The SURMOUNT-4 trial followed tirzepatide patients to a mean 20.9% weight loss, then switched half to placebo
Over time, this can lead to irregular periods, missed ovulation, or your period stopping altogether (called weight loss-related amenorrhea)
For now, the study provides reassurance, not a green light to continue GLP-1 medications during pregnancy without medical guidance.
However, 13-week Phase 2 data in 125 patients cannot be meaningfully compared to 68-week Phase 3 data in 1,961 patients
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