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Endogenous MOTS-c rises during exercise in humans, suggesting it is part of the natural exercise-adaptation signaling

Leprevost L, Jnger S, Lippens G, Guillaume C, Sicoli G, Oliveira L, Falcone E, de Santis E, Rivera-Millot A, Billon G, Stellato F, Henry C, Antoine R, Zirah S, Dubiley S, Li Y, Jacob-Dubuisson F (2024) Proc Natl Acad Sci 121:e2408304121

So what scientists don't really know yet is whether all these benefits are really just due to the weight loss and people shedding pounds, and thus being a healthier weight, or whether there's some other biological mechanism at play