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MnO x nanospikes, as TME-responsive nano-adjuvants and immunogenic cell death drugs, were also designed for cancer nanovaccine-based immunotherapy ( 2 and Fe 3 O 4 were co-loaded on to dendritic mesoporous silica NPs, researchers showed that these particles can achieve tumor specialized localization and induction of Fenton reaction, thus triggering ferroptosis (Li and Rong, 2020)

However, when CoQ10 and L-Carnitine are used in combination therapies, the results are far more promising, with ongoing research into mitochondrial nutrients continuing to expand across the medical and pharmacological literature

Adam et al., University of Washington, Seattle, 1993

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