tirzepatide and bone loss GLP-1 medications like Ozempic (semaglutide) Mounjaro (tirzepatide) are helping millions of people lose weight. The results are real, and for many patients the metabolic benefits are life-changing. But there's a trade-off I kept seeing patients on

Monitoring schedule Healthcare providers who specialize in GLP-1 therapy typically recommend this monitoring cadence: Baseline: Full B12 panel before starting semaglutide 3 months: Repeat serum B12 and MMA 6 months: Full panel reassessment Annually: Once stable, annual monitoring is usually sufficient For high-risk patients (metformin users, vegans, those over 60, post-bariatric surgery), the 3-month check is particularly important

It is licensed only for type 2 diabetes mellitus, and prescribing it solely for PCOS would be considered off-label use

During the first eight weeks, which covers the 0.25 mg and 0.5 mg doses, average weight loss hovers around a modest 1.1 to 1.5 percent of total body weight

Astrocyte metabolism and signaling during brain ischemia