The TGA reports a number of adverse events and other concerns received for unapproved peptide products, which include: severe allergic reactions, requiring doses of adrenaline and hospitalisation systemic inflammatory response syndrome (SIRS) (severe inflammation in the body), requiring hospital management generalised hypersensitivity symptoms such as fullbody intense itching, palpitations, pain and sweating wide ranging body side effects, including insomnia, blurred vision, extreme tiredness, flulike illness, joint pain and skin sensitivity musculoskeletal injuries, including plantar fasciitis and Achilles tendinitis, and poor product quality, including unsealed packaging from an online supplier
doi: 10.1097/ADM.0b013e318193c993, 48 GearhardtA
10.1016/j.jaci.2004.05.013
For most people its indirect: appetite drops, total calories fall, protein slips, fluids/electrolytes drop, and nausea or constipation reduces intake even more