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PEX-168 improves insulin resistance, inflammatory response and adipokines in simple obese mice: a mechanistic exploration
GLP-1 has another beneficial effect in type 2 diabetes that contributes to maintaining euglycaemia: in type 2 diabetes glucagon secretion is excessively stimulated and glucagon stimulates hepatic glucose production
Bias between mini-G s and -arrestin-2 recruitment was determined similarly to earlier work (Pickford et al ., 2020), by subtracting the log /K values (Kenakin et al ., 2012) for each ligand in each pathway for each assay to determine log /K A (referred to here as LogR)
The measurement of TCN2-Cbl provides a more accurate reflection of the vitamin B12 status, particularly in the context of neurological disorders, as it specifically quantifies the fraction of Cbl bound to TCII and available for cellular uptake and metabolism [133]
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