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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism
Unique peptides for the quantification of UGT2B15 were IHHDQPMKPLDR, SVINDPVYKENVMK, NYLEDSLLK, ILDRWIYGVSK, SVINDPVYK and for UGT2B17 were FSVGYTVEK, LCEDAVLNKK, SVINDPIYKENIMK, NDLEDFFMK, LCEDAVLNK
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