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Ferritinophagy is a key mechanism for rapidly increasing the iron content of the LIP when needed and is important for increasing cellular sensitivity to ferroptosis (25)
This helps reduce uneven pigmentation and promotes a brighter, more even-looking complexion over time
Jan 8: Astellas has failed to gain approval for what would be the first approved therapy targeting claudin 18.2 (CLDN18.2), a transmembrane protein expressed on the surface of gastric epithelial cancer cells
471 Knocking down FTH in cardiomyocytes prevents free iron from being stored in ferritin, increases unstable iron pools, promotes intracellular ROS production, activates oxidative stress, and causes ferroptosis in cardiomyocytes, leading to age-related heart damage
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