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J Neurosci 27 : 54745483
Haag and coworkers developed biodegradable polyglycerol nanogels where biodegradability was achieved by introducing the pH-cleavable acetal linkage at the junction between two different polyglycerol building blocks 147
There is one small pilot study in humans (examining knee pain, where 7 of 12 participants reported sustained improvement beyond 6 months) and a 2025 safety study confirming BPC-157 was well tolerated in healthy adults
doi:10.1016/j.rmed.2018.10.016
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