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SNAC was originally developed by Emisphere, and has been granted GRAS (generally recognized as safe) status by the FDA for use with food supplements, vitamins and dietary ingredients (256)
Normally produced in the lizard salivary gland, exendin can bind mammalian GLP-1R and bolster its activity
The return of appetite is not evidence of metabolic damage but rather the removal of pharmacological appetite suppression
Weight loss typically continues for 12 to 18 months before plateauing
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