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Oct 1998;3(5):295-302

In addition to serving as a substrate for protein synthesis, Trp is metabolized through the Kyn pathway via IDO1/tryptophan 2,3-dioxygenase (TDO) to generate metabolites such as Kyn, which can influence inflammatory transcription and immune tolerance through signaling axes such as the AhR ( In the immune microenvironment, Trp can enter the Kyn pathway through IDO1 or TDO, generating Kyn and its downstream metabolites

It is used as a supplement for people with alcoholic liver diseases (damage to the liver due to overconsumption of alcohol) like liver fibrosis, fatty liver, cirrhosis, and hepatitis

Although low levels of reactive oxygen species (ROS) mediate critical physiological signaling pathways, accumulation of raised levels, if not cleared rapidly, can lead to major deleterious consequences affecting several organs, such as the heart, kidney, eye and brain, culminating in a variety of human disorders (Forman and Zhang 2021)