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While there are big reasons for this, like well-publicized research about the impact alcohol has on health and a general decline in social activities among Gen Z, one connection thats only just getting some attention is that between GLP-1 medications, like semaglutide and tirzepatide, and alcohol use

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No severe or confirmed hypoglycaemic episodes were reported in the two trials and there were no clinically relevant observations related to vital signs, physical examination, electrocardiogram or laboratory safety parameters, except temporary asymptomatic increases in lipase levels in two subjects at follow-up in the dosing conditions trial (from 46 U/L at screening to 231 U/L at follow-up and from 59 U/L at screening to 378 U/L at follow-up [normal range 1360 U/L])

use only if medically advised