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This deficiency can result from conditions such as pernicious anemia, certain gastrointestinal disorders, or a diet low in animal products
This finding has important safety implications, as elevated IGF-1 levels associated with full GH therapy raise concerns about increased cancer risk, particularly for individuals with pre-existing malignancies or strong family histories
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By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl sink, increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NAD
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