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Our finding of a significant reduction in CKD progression outcome in association with GLP1-RA use is also consistent with the findings of the FLOW study 44
Also sustaining this hypothesis, other authors observed that modulation of IGF-1R-associated genes promoted regulatory clustering as well as stemness and chemoresistance in cells from colorectal cancer patients and mouse models, and was facilitated by a master transcriptional regulator responsive to ribosomal dysfunction, PR domain zinc finger protein 1 (PRDM1) (49)
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